HPC羟基丙基纤维素.docx

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1、HydroxypropylCellulose(HPC)HIGH-SubstituteHydroxypropylCelluIose(H-HPC)BriefIntroductionH-HPCcanbeusedasabinderfortabletsandgranulesinthepharmaceuticalfield,whichcanincreasethestabilityandimprovethehardnessofthetablets.H-HPChasexcellentfilm-formingproperties,whicharetoughandelastic,anditisalsoafanta

2、sticfilm-coatingmaterial.TechnicalSpecificationsItemUnitStandardHydroxypropoxy%55.0-77.0Lossondrying%7.0Residueonignition%1.0PH5.08.0VitalcelloseViscosityConcentrationinwater;Weight,%M4000-65002%G150-4002%J150-4005%L75-1505%Package:25KGbarrel;orcustomizedpacking.HydroxypropylCellulose(HPC)1.owSubsti

3、tuteHydroxypropylCelluIose(L-HPC)1.ow-substitutedhydroxypropylcelluloseisamedicinalauxiliarymaterialspeciallymanufacturedfortabletproduction.Thisproductismadeofalkalicelluloseasrawmaterialthroughpropyleneoxideetherification.Thestructurecontainsmanyhydrophilicgroups,avastinnersurfaceandporosity,fastm

4、oistureabsorption,andahighswellingrate(muchbetterthanstarch),whichcanacceleratethedisintegrationoftabletswithpoordisintegrationandimprovethedispersion.Inaddition,thetabletsfinenesscanacceleratethedrugsdissolutionrate.Atthesametime,itsroughstructurecanhaveamoresignificantinlaideffectonthepill,enhanci

5、ngthebondingstrengthandtherebyimprovingthehardnessandsmoothnessofthetablet.Therefore,itisthepreferreddisintegrantofthetablet.TechnicalSpecificationsVitalcelloseApplicationAssayParticleSizeLHllDisintegranttopreventthetabletcrackfordirectcompression10.0-12.9%55mLH21Disintegrantandadhesivetotabletforwetgranulation10.0-12.9%45mLH22Normaldisintegrant,fornormaladhesiveforcerequirements7.0-9.9%45mComplytoUSP/EPstandardPackage:25kgBarrelor25kgBag