腹膜透析基础.ppt
《腹膜透析基础.ppt》由会员分享,可在线阅读,更多相关《腹膜透析基础.ppt(75页珍藏版)》请在优知文库上搜索。
1、 腹膜透析腹膜透析ESRD治疗治疗 How PD works 腹腹 透透 原原 理理 What is the peritoneal membrane?腹膜是被覆于腹腔的光腹膜是被覆于腹腔的光滑滑浆膜膜n脏层腹膜脏层腹膜n壁层腹膜壁层腹膜n腹膜凹陷腹膜凹陷n腹腔和腹膜腔腹腔和腹膜腔The mesotheliumThe interstitiumMacrophages/MonocytesPeritoneal capillariesPlays important role water and solute exchange间皮皮间质巨噬细胞/单核细胞腹膜毛细血管在水和溶质的转换中起重要作用Compon
2、ents of the peritoneum Role of the peritoneum 腹膜的功能腹膜的功能nProtect peritoneal organsnPrevent friction of moving organsnHost defense mechanisms:nMesothelial cells,monocytesmacrophages,opsoninsn支持、保护腹腔脏器n分泌滑液防止脏器移动时的摩擦n宿主的防御机制:n间皮细胞、单核巨噬细胞、调理素 Components of the peritoneum as a dialysis membrane 腹膜(做为透析膜
3、)的组成腹膜(做为透析膜)的组成The mesotheliumThe stagnant fluid film The interstitiumPeritoneal capillariesStagnant capillary fluidThe capillary endothelium itselfThe endothelial basement membrane间皮滞留液体层(阻力)间质 腹膜毛细血管毛细血管滞留液体毛细血管内皮内皮基底膜The transport of solutes and water across a“membrane”that separates two fluid c
4、ontaining compartments.The blood in the peritoneal capillariesDialysis solution in the peritoneal cavity腹膜将下列两种液体分隔,水分和溶质进行跨膜转运n腹膜毛细血管中的血液n腹腔中的透析液A Basic Concept of Peritoneal Dialysis 腹透基本概念腹透基本概念PERITONEAL TISSUEBLOOD腹膜组织腹膜组织血液血液Membrane腹膜腹膜PERITONEAL CAVITY DIALYSATE腹腔腹腔透析液透析液Membrane model腹膜模型腹膜
5、模型Removal of uremic toxins 尿毒症毒素清除尿毒症毒素清除 Small solutes Diffusion:Convective transport Middle or large solutes Peritoneal leak 小分子溶质 弥散:对流转运:中等或大分子溶质 腹膜渗漏Diffusion 弥散弥散Definition:Solute movement due to concentration gradient of two solutes between components across a semi-permeable membraneMain driv
6、ing force for small solute removalFactors involved in diffusion Size of solute Peritoneal surface area Hydrostatic pressure Electrical charge of solutes定义:溶质依靠溶液之间浓度梯度透过半透膜(腹膜)进行的转运弥散是小分子溶质清除的主要机制影响弥散的因素 溶质分子的大小 腹膜表面积 静水压 溶质的电负荷Convective transport 对流转运对流转运 Solute transport along with fluid movement
7、 High during active ultrafiltration Terms used in convective transport Sieving coefficient:Ratio of solute being passed the barrier Reflection coefficientRatio of solute being rejected by the barrierSieving coefficient=1-reflection coefficient Factors involved in convective transportSize of solute E
8、lectrical charge of solutes 定义:水分转运时伴随的溶质清除 高效超滤过程中对流作用大 对流转运应用的参数 筛选系数(Sieving coefficient):溶质通过膜屏障的比例 反射系数(Reflection coefficient):溶质被膜屏障阻挡的比例 筛选系数1反射系数 影响对流转运的因素 溶质分子的大小 溶质的电负荷Osmotic UltrafiltrationMovement of water from a chamber with lower osmotic pressure to higher one across a semi-permeable
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 腹膜 透析 基础